Alex Kurilshikov

Alex is a postdoc working on microbiome research at the University Medical Center Groningen. His team aims to explore the interactions between the human microbiome and other kind of human ‘omics’ data to investigate the possible impact of the microbiota on human health.

Using data from the LifeLines-DEEP population cohort, they showed how the gut microbiome is shaped by external and intrinsic factors such as diet, medication and diseases (Zhernakova et al, Science, 2016). Now Alex is focusing on further analysis of the microbiome’s role in shaping human serum metabolism, which is the key element in many metabolic disorders and cardiovascular disease events.


Impact of occupational pesticide exposure on the human gut microbiome

Milla F Brandao Gois, Asier Fernández-Pato, Anke Huss, Ranko Gacesa, Cisca Wijmenga, Rinse K Weersma, Jingyuan Fu, Roel C H Vermeulen, Alexandra Zhernakova, Virissa C Lenters, Alexander Kurilshikov
Front. Microbiol., 10 August 2023 Sec. Microbial Symbioses Volume 14 - 2023 |

Integrated fecal microbiome-metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome

Zlatan Mujagic, Melpomeni Kasapi, Daisy Mae Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R M Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K Nicholson, Joram M Posma, Ad Am Masclee
Gut Microbes, vol. 14 issue 1

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study

Marwah Doestzada, Daria V. Zhernakova, Inge C. L. van den Munckhof, Daoming Wang, Alexander Kurilshikov, Lianmin Chen,Vincent W. Bloks, Martijn van Faassen, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers, and Jingyuan Fu
BMC Medicine, vol. 20 issue 1

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Lianmin Chen, Daria V Zhernakova, Alexander Kurilshikov, Sergio Andreu-Sánchez, Daoming Wang, Hannah E Augustijn, Arnau Vich Vila; Lifelines Cohort Study; Rinse K Weersma, Marnix H Medema, Mihai G Netea, Folkert Kuipers, Cisca Wijmenga, Alexandra Zhernakova, Jingyuan Fu
Nature medicine, vol. 28 issue 11

Role of the gut microbiome in mediating lactose intolerance symptoms

Brandao Gois MF, Sinha T, Spreckels JE et al.
Gut, vol. 71 issue 1

Environmental factors shaping the gut microbiome in a Dutch population

R. Gacesa, A. Kurilshikov, A. Vich Vila, T. Sinha, M.A.Y. Klaassen L.A. Bolte, S. Andreu-Sánchez, L. Chen, V. Collij, S. Hu, J.A.M. Dekens, V.C. Lenters, J.R. Björk, J.C. Swarte, M.A. Swertz, B.H. Jansen, J. Gelderloos-Arends, S. Jankipersadsing, M. Hofker, R.C.H. Vermeulen, S. Sanna, H.J.M. Harmsen, C. Wijmenga, J. Fu, A. Zhernakova, R.K. Weersma
Nature (2022)

Alex Kurilshikov

Contact information

University Medical Center Groningen
Department of Genetics, CB50
Building 3211; PO Box 30001
9700 RB Groningen
The Netherlands


Areas of Expertise

Bioinformatics Genetics Microbiomics

Decoding the exposome

Decoding the exposome

The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...

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