Integrating the UK Biobank’s comprehensive multi-omics data with EXPANSE’s high-resolution exposure maps will provide a powerful framework for testing and implementing novel methods to study and establish how gene-environment interaction.
This project aims to harmonize efforts between genomics and exposomics researchers. After development of methods within the UK Biobank, the work will be extended to other datasets enriched with genetics data (e.g. Lifelines), promising to yield actionable biological insights.
The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...
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