The aim of this project is to identify and functionally validate internal Exposome markers that trigger and drive vascular disease and CMD. Moreover, we want to obtain mechanistic insights into pathways underlying internal Exposome markers identified in research project 'Linking the Internal Exposome to Cardiometabolic Disease' and identify key perturbated pathways during the onset of CMD that are modifiable.
We know far less about the exposome than we do about the human genome. So far, we only understand about half of the disease burden for which we know the environment plays a role. If we want to prevent people from becoming ill, then we need to understand the other half too. We therefore want to systematically analyse the exposome for the first time. We will start with research into the causes of cardiovascular disease and type 2 diabetes. The techniques and insights from this research will also be applicable to other chronic conditions.Read More