I.C 1 Endogenous components as short term read outs of the exposome

A critical component of the Exposome is linking exogenous exposures to both internal dose and associated biological response. For example: we can measure acute exposure to pollutants, drugs, nutrients in blood or urine; exposure to these compounds can initiate local and global changes in gene methylation and transcription, and metabolite and microbiome pathway alterations.

As a result, micro- and macroscale interactions occur among these systems that can be characterised to study exposure–response relationships. Measurements can provide information on acute biological responses that occur at a biologically relevant dose and also on whether long-term alterations in physiology—that is, markers of exposure memory—have been detected from environmental stressors occurring years or decades before.

Decoding the exposome

Decoding the exposome

Exposome-NL is a Dutch consortium of over fifty scientists from different disciplines, universities and medical centres. Together the scientists will systematically sequence the environmental factors influencing our health.

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