II.B Linking the Internal Exposome to Cardiometabolic Disease

Measures of the internal Exposome include the analysis of metabolome, microbiome, transcriptomics, proteomics and epigenetics. These omics layers form a complex integration of the effects of the external Exposome with individual’s inborn factors, genetic background and allostatic load.

The goal of this research project is to identify the internal Exposome factors causal for Cardiometabolic Health, their interaction with host genetics and the external Exposome, and to build a predictive Exposome model of Cardiometabolic Disease development.

Publications

Environmental factors shaping the gut microbiome in a Dutch population

R. Gacesa, A. Kurilshikov, A. Vich Vila, T. Sinha, M.A.Y. Klaassen L.A. Bolte, S. Andreu-Sánchez, L. Chen, V. Collij, S. Hu, J.A.M. Dekens, V.C. Lenters, J.R. Björk, J.C. Swarte, M.A. Swertz, B.H. Jansen, J. Gelderloos-Arends, S. Jankipersadsing, M. Hofker, R.C.H. Vermeulen, S. Sanna, H.J.M. Harmsen, C. Wijmenga, J. Fu, A. Zhernakova, R.K. Weersma
Nature (2022)

Environmental risk factors of type 2 diabetes-an exposome approach

Beulens JWJ, Pinho MGM, Abreu TC, den Braver NR, Lam TM, Huss A, Vlaanderen J, Sonnenschein T, Siddiqui NZ, Yuan Z, Kerckhoffs J, Zhernakova A, Brandao Gois MF, Vermeulen RCH.
Diabetologia. 2021 Nov 18.

Decoding the exposome

Decoding the exposome

Exposome-NL is a Dutch consortium of over fifty scientists from different disciplines, universities and medical centres. Together the scientists will systematically sequence the environmental factors influencing our health.

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