Measures of the internal Exposome include the analysis of metabolome, microbiome, transcriptomics, proteomics and epigenetics. These omics layers form a complex integration of the effects of the external Exposome with individual’s inborn factors, genetic background and allostatic load.
The goal of this research project is to identify the internal Exposome factors causal for Cardiometabolic Health, their interaction with host genetics and the external Exposome, and to build a predictive Exposome model of Cardiometabolic Disease development.
R. Gacesa, A. Kurilshikov, A. Vich Vila, T. Sinha, M.A.Y. Klaassen L.A. Bolte, S. Andreu-Sánchez, L. Chen, V. Collij, S. Hu, J.A.M. Dekens, V.C. Lenters, J.R. Björk, J.C. Swarte, M.A. Swertz, B.H. Jansen, J. Gelderloos-Arends, S. Jankipersadsing, M. Hofker, R.C.H. Vermeulen, S. Sanna, H.J.M. Harmsen, C. Wijmenga, J. Fu, A. Zhernakova, R.K. Weersma
Nature (2022)
Beulens JWJ, Pinho MGM, Abreu TC, den Braver NR, Lam TM, Huss A, Vlaanderen J, Sonnenschein T, Siddiqui NZ, Yuan Z, Kerckhoffs J, Zhernakova A, Brandao Gois MF, Vermeulen RCH.
Diabetologia. 2021 Nov 18.
The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...
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