This research project aims to overcome current challenges in linking the general and specific external exposome to human health using Cardiometabolic Disease (CMD) as example. We aim to explain the risk of CMD unaccounted for by other established risk factors.
Based on research line 1 (measuring the exposome) we will validate and use novel measures of the general external exposome in relation to CMD, accounting for the time and space specific relation between measures of the external exposome and CMD.
Next, we will use the specific external exposome to explain the relation of the general external exposome with CMD via causation (e.g., influence of an unhealthy food environment on CMH via dietary intake) or selection (e.g. wealthier, active individuals being able to afford a house in a wealthy neighbourhood that enables physical activity).
Mingwei Liu, Paul Meijer, Thao Minh Lam, Erik J Timmermans, Diederick E Grobbee, Joline W J Beulens, Ilonca Vaartjes, Jeroen Lakerveld
European Journal of Preventive Cardiology
Nicolette R. den Braver; Joline W.J. Beulens; C. Fangyun Wu; Ghazal S. Fazli; Peter Gozdyra; Nicholas A. Howell; Jeroen Lakerveld; John S. Moin; Femke Rutters; Johannes Brug; Rahim Moineddin; Gillian L. Booth
Diabetes Care, dc221549
Thao Minh Lam, Alfred J. Wagtendonk, Nicolette R. den Braver, Derek Karssenberg, Ilonca Vaartjes, Erik J. Timmermans, Joline W. J. Beulens, Jeroen Lakerveld
Obesity, volume 31, issue 1
Haykanush Ohanyan, Lützen Portengren, Anke Huss, Eugenio Traini, Joline W.J. Beulens, Gerard Hoek, Jeroen Lakerveld, Roel Vermeulen
Environment International (158), Jan 2022
Pinho MGM, Lakerveld J, Harbers MC, Sluijs I, Vermeulen R, Huss A, Boer JMA, Verschuren WMM, Brug J, Beulens JWJ, Mackenbach JD.
European Journal of Nutrition. 60 (2021).
The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...Read More