This research project aims to overcome current challenges in linking the general and specific external exposome to human health using Cardiometabolic Disease (CMD) as example. We aim to explain the risk of CMD unaccounted for by other established risk factors.
Based on research line 1 (measuring the exposome) we will validate and use novel measures of the general external exposome in relation to CMD, accounting for the time and space specific relation between measures of the external exposome and CMD.
Next, we will use the specific external exposome to explain the relation of the general external exposome with CMD via causation (e.g., influence of an unhealthy food environment on CMH via dietary intake) or selection (e.g. wealthier, active individuals being able to afford a house in a wealthy neighbourhood that enables physical activity).
Exposome-NL is a Dutch consortium of over fifty scientists from different disciplines, universities and medical centres. Together the scientists will systematically sequence the environmental factors influencing our health.Read More