I.C 2 Endogenous components as long term read outs of the exposome

A critical component of the Exposome is linking exogenous exposures to both internal dose and associated biological response. For example: we can measure acute exposure to pollutants, drugs, nutrients in blood or urine; exposure to these compounds can initiate local and global changes in gene methylation and transcription, and metabolite and microbiome pathway alterations.

As a result, micro- and macroscale interactions occur among these systems that can be characterised to study exposure–response relationships. Measurements can provide information on acute biological responses that occur at a biologically relevant dose and also on whether long-term alterations in physiology—that is, markers of exposure memory—have been detected from environmental stressors occurring years or decades before.


Integrated fecal microbiome-metabolome signatures reflect stress and serotonin metabolism in irritable bowel syndrome

Zlatan Mujagic, Melpomeni Kasapi, Daisy Mae Jonkers, Isabel Garcia-Perez, Lisa Vork, Zsa Zsa R M Weerts, Jose Ivan Serrano-Contreras, Alexandra Zhernakova, Alexander Kurilshikov, Jamie Scotcher, Elaine Holmes, Cisca Wijmenga, Daniel Keszthelyi, Jeremy K Nicholson, Joram M Posma, Ad Am Masclee
Gut Microbes, vol. 14 issue 1

Faecal metabolome and its determinants in inflammatory bowel disease

Arnau Vich Vila, Shixian Hu, Sergio Andreu-Sánchez, Valerie Collij, Bernadien H Jansen, Hannah E Augustijn, Laura A Bolte, Renate A A A Ruigrok, Galeb Abu-Ali, Cosmas Giallourakis , Jessica Schneider, John Parkinson, Amal Al-Garawi, Alexandra Zhernakova, Ranko Gacesa, Jingyuan Fu, Rinse K Weersma
Gut (March 2023)

Systematic analysis of relationships between plasma branched-chain amino acid concentrations and cardiometabolic parameters: an association and Mendelian randomization study

Marwah Doestzada, Daria V. Zhernakova, Inge C. L. van den Munckhof, Daoming Wang, Alexander Kurilshikov, Lianmin Chen,Vincent W. Bloks, Martijn van Faassen, Joost H. W. Rutten, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, Niels P. Riksen, Alexandra Zhernakova, Folkert Kuipers, and Jingyuan Fu
BMC Medicine, vol. 20 issue 1

Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

Lianmin Chen, Daria V Zhernakova, Alexander Kurilshikov, Sergio Andreu-Sánchez, Daoming Wang, Hannah E Augustijn, Arnau Vich Vila; Lifelines Cohort Study; Rinse K Weersma, Marnix H Medema, Mihai G Netea, Folkert Kuipers, Cisca Wijmenga, Alexandra Zhernakova, Jingyuan Fu
Nature medicine, vol. 28 issue 11

gutSMASH predicts specialized primary metabolic pathways from the human gut microbiota

Victòria Pascal Andreu, Hannah E Augustijn, Lianmin Chen, Alexandra Zhernakova, Jingyuan Fu, Michael A Fischbach, Dylan Dodd, Marnix H Medema
Nature biotechnology (Feb 2023)

Decoding the exposome

Decoding the exposome

The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...

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