This project aims to advance the detection and analysis of small molecules within the human exposome using high-resolution mass spectrometry (HRMS). The primary goal is to enhance the identification, quantification, and sensitivity of Exposome Scans, making them more cost-effective and accessible for applications ranging from citizen science to environmental health assessments.
Furthermore, we will develop workflows to annotate previously unidentified small molecules, assess the environmental exposure impacts human metabolism and immunity, and advance methods for the precise quantification of detected molecules.
The research will refine data processing pipelines, integrate biomarkers for exposure and health effects, and utilize advanced sampling techniques to improve sensitivity. By exploring strategies to reduce costs without compromising data quality, this project will provide essential tools and methodologies to support the broader Exposome-NL program.
The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...
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