Publications

Bioinformatics

Air pollution in relation to brain health indicators and global cognitive functioning in patients with cardiovascular disorders along the heart-brain axis

Timmermans, E.J., Bron, E.E., Bots, M.L., Leeuwis, A.E., Moonen, J.E.F., Wolters, F.J., Biessels, G.J., & Vaartjes, I., on behalf of the Heart-Brain Connection Consortium
Cerebral Circulation – Cognition and Behavior (2026)

Linking the gut microbiome to host DNA methylation by a discovery and replication epigenome-wide association study

Demirkan A, van Dongen J, Finnicum CT, Westra HJ, Jankipersadsing S, Willemsen G, Ijzerman RG, Boomsma DI, Ehli EA, Bonder MJ, Fu J, Franke L, Wijmenga C, de Geus EJC, Kurilshikov A, Zhernakova A.
BMC Genomics (2024)

Epigenome-wide association study on the plasma metabolome suggests self-regulation of the glycine and serine pathway through DNA methylation

Wu J, Palasantzas V, Andreu-Sánchez S, Plösch T, Leonard S, Li S, Bonder MJ, Westra HJ, van Meurs J, Ghanbari M, Franke L, Zhernakova A, Fu J, Hoogerland JA, Zhernakova DV.
Clinical Epigenetics (2024)

Linked shrinkage to improve estimation of interaction effects in regression models

Mark A. van de Wiel , Matteo Amestoy and Jeroen Hoogland
Epidemiologic Methods (2024)

Exposome-Wide Association Study of Body Mass Index Using a Novel Meta-Analytical Approach for Random Forest Models

Haykanush Ohanyan , Mark van de Wiel, Lützen Portengen, Alfred Wagtendonk, Nicolette R. den Braver, Trynke R. de Jong, Monique Verschuren, Katja van den Hurk, Karien Stronks, Eric Moll van Charante, Natasja M. van Schoor, Coen D.A. Stehouwer, Anke Wesselius, Annemarie Koster, Margreet ten Have, Brenda W.J.H. Penninx, Marieke F. van Wier, Irina Motoc, Albertine J. Oldehinkel, Gonneke Willemsen, Dorret I. Boomsma, Mariëlle A. Beenackers, Anke Huss, Martin van Boxtel, Gerard Hoek, Joline W.J. Beulens, Roel Vermeulen, and Jeroen Lakerveld
Environmental Health Perspectives, Volume 132, Issue 6 (2024)

Decoding the exposome

Decoding the exposome

The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...

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