Publicaties

Association between gut microbiome profiles and host metabolic health across the life course: a population-based study

Li R, Kurilshikov A, Yang S, van Oortmerssen JAE, van Hilten A, Ahmadizar F, Roshchupkin G, Kraaij R, Duijts L, Fu J, Ikram MK, Jaddoe VWV, Uitterlinden AG, Rivadeneira F, Kavousi M, Zhernakova A, Medina-Gomez C.
Lancet Reg Health Eur (2024)

Maternal antibiotic prophylaxis during cesarean section has a limited impact on the infant gut microbiome

Sinha T, Prins JR, Fernández-Pato A, Kruk M, Dierikx T, de Meij T, de Boer M, de Boer JF, Scherjon S, Kurilshikov A, Zhernakova A.
Cell Host Microbe (2024)

Intestinal Blastocystis is linked to healthier diets and more favorable cardiometabolic outcomes in 56,989 individuals from 32 countries

Piperni E, Nguyen LH, Manghi P, Kim H, Pasolli E, Andreu-Sánchez S, Arrè A, Bermingham KM, Blanco-Míguez A, Manara S, Valles-Colomer M, Bakker E, Busonero F, Davies R, Fiorillo E, Giordano F, Hadjigeorgiou G, Leeming ER, Lobina M, Masala M, Maschio A, McIver LJ, Pala M, Pitzalis M, Wolf J, Fu J, Zhernakova A, Cacciò SM, Cucca F, Berry SE, Ercolini D, Chan AT, Huttenhower C, Spector TD, Segata N, Asnicar F.
Cell (2024)

Antibody signatures against viruses and microbiome reflect past and chronic exposures and associate with aging and inflammation

Andreu-Sánchez S, Ripoll-Cladellas A, Culinscaia A, Bulut O, Bourgonje AR, Netea MG, Lansdorp P, Aubert G, Bonder MJ, Franke L, Vogl T, van der Wijst MGP, Melé M, Van Baarle D, Fu J, Zhernakova A.
iScience (2024)

Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits

Camargo Tavares L, Lopera-Maya EA, Bonfiglio F, Zheng T, Sinha T, Zanchetta Marques F, Zhernakova A, Sanna S, D'Amato M.
Cell Mol Gastroenterol Hepatol (2024)

Unraveling interindividual variation of trimethylamine N-oxide and its precursors at the population level

Andreu-Sánchez S, Ahmad S, Kurilshikov A, Beekman M, Ghanbari M, van Faassen M, van den Munckhof ICL, Steur M, Harms A, Hankemeier T, Ikram MA, Kavousi M, Voortman T, Kraaij R, Netea MG, Rutten JHW, Riksen NP, Zhernakova A, Kuipers F, Slagboom PE, van Duijn CM, Fu J, Vojinovic D.
Imeta (2024)

Choice of DNA extraction method affects stool microbiome recovery and subsequent phenotypic association analyses

Fernández-Pato A, Sinha T, Gacesa R, Andreu-Sánchez S, Gois MFB, Gelderloos-Arends J, Jansen DBH, Kruk M, Jaeger M, Joosten LAB, Netea MG, Weersma RK, Wijmenga C, Harmsen HJM, Fu J, Zhernakova A, Kurilshikov A.
Scientific Reports (2024)

Host genetic regulation of human gut microbial structural variation

Zhernakova DV, Wang D, Liu L, Andreu-Sánchez S, Zhang Y, Ruiz-Moreno AJ, Peng H, Plomp N, Del Castillo-Izquierdo Á, Gacesa R, Lopera-Maya EA, Temba GS, Kullaya VI, van Leeuwen SS; Lifelines Cohort Study; Xavier RJ, de Mast Q, Joosten LAB, Riksen NP, Rutten JHW, Netea MG, Sanna S, Wijmenga C, Weersma RK, Zhernakova A, Harmsen HJM, Fu J.
Nature (2024)

Gut feelings: the relations between depression, anxiety, psychotropic drugs and the gut microbiome

Brushett S, Gacesa R, Vich Vila A, Brandao Gois MF, Andreu-Sánchez S, Swarte JC, Klaassen MAY, Collij V, Sinha T, Bolte LA, Wu J, Swertz M, de Kroon MLA, Reijneveld SA, Wijmenga C, Weersma RK, Fu J, van Loo HM, Kurilshikov A, Zhernakova A.
Gut Microbes (2023)

Analysis of microbial composition and sharing in low-biomass human milk samples: a comparison of DNA isolation and sequencing techniques

Spreckels JE, Fernández-Pato A, Kruk M, Kurilshikov A, Garmaeva S, Sinha T, Ghosh H, Harmsen H, Fu J, Gacesa R, Zhernakova A.
ISME Commun (2023)

Gut dysbiosis associates with cytokine production capacity in viral-suppressed people living with HIV

Zhang Y, Andreu-Sánchez S, Vadaq N, Wang D, Matzaraki V, van der Heijden WA, Gacesa R, Weersma RK, Zhernakova A, Vandekerckhove L, de Mast Q, Joosten LAB, Netea MG, van der Ven AJAM, Fu J.
Front Cell Infect Microbiol (2023)

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire

Andreu-Sánchez S, Bourgonje AR, Vogl T, Kurilshikov A, Leviatan S, Ruiz-Moreno AJ, Hu S, Sinha T, Vich Vila A, Klompus S, Kalka IN, de Leeuw K, Arends S, Jonkers I, Withoff S; Lifelines Cohort Study; Brouwer E, Weinberger A, Wijmenga C, Segal E, Weersma RK, Fu J, Zhernakova A.
Immunity (2023)

Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures

Bourgonje AR, Andreu-Sánchez S, Vogl T, Hu S, Vich Vila A, Gacesa R, Leviatan S, Kurilshikov A, Klompus S, Kalka IN, van Dullemen HM, Weinberger A, Visschedijk MC, Festen EAM, Faber KN, Wijmenga C, Dijkstra G, Segal E, Fu J, Zhernakova A, Weersma RK.
Immunity (2023)

The maternal gut microbiome during pregnancy and its role in maternal and infant health

Sinha T, Brushett S, Prins J, Zhernakova A.
Curr Opin Microbiol (2023)

Microbial vitamin production mediates dietary effects on diabetic risk

Wang D, Pham VT, Steinert RE, Zhernakova A, Fu J.
Gut Microbes (2022)

Diversity and Ecology of Caudoviricetes Phages with Genome Terminal Repeats in Fecal Metagenomes from Four Dutch Cohorts

Gulyaeva A, Garmaeva S, Kurilshikov A, Vich Vila A, Riksen NP, Netea MG, Weersma RK, Fu J, Zhernakova A.
Viruses (2022)

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

Camilleri M, Zhernakova A, Bozzarelli I, D'Amato M.
Nat Rev Gastroenterol Hepatol (2022)

Challenges and future directions for studying effects of host genetics on the gut microbiome

Sanna S, Kurilshikov A, van der Graaf A, Fu J, Zhernakova A.
Nature Genetics (2022)

Yoghurt consumption is associated with changes in the composition of the human gut microbiome and metabolome

Le Roy CI, Kurilshikov A, Leeming ER, Visconti A, Bowyer RCE, Menni C, Falchi M, Koutnikova H, Veiga P, Zhernakova A, Derrien M, Spector TD.
BMC Microbiol (2022)

Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota

Vogl T, Klompus S, Leviatan S, Kalka IN, Weinberger A, Wijmenga C, Fu J, Zhernakova A, Weersma RK, Segal E.
Nature Medicine (2021)

Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome

Bolte LA, Vich Vila A, Imhann F, Collij V, Gacesa R, Peters V, Wijmenga C, Kurilshikov A, Campmans-Kuijpers MJE, Fu J, Dijkstra G, Zhernakova A, Weersma RK.
Gut (2021)

Large-scale association analyses identify host factors influencing human gut microbiome composition

Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, Zhernakova DV, Bonder MJ, Hansen TH, Frost F, Rühlemann MC, Turpin W, Moon JY, Kim HN, Lüll K, Barkan E, Shah SA, Fornage M, Szopinska-Tokov J, Wallen ZD, Borisevich D, Agreus L, Andreasson A, Bang C, Bedrani L, Bell JT, Bisgaard H, Boehnke M, Boomsma DI, Burk RD, Claringbould A, Croitoru K, Davies GE, van Duijn CM, Duijts L, Falony G, Fu J, van der Graaf A, Hansen T, Homuth G, Hughes DA, Ijzerman RG, Jackson MA, Jaddoe VWV, Joossens M, Jørgensen T, Keszthelyi D, Knight R, Laakso M, Laudes M, Launer LJ, Lieb W, Lusis AJ, Masclee AAM, Moll HA, Mujagic Z, Qibin Q, Rothschild D, Shin H, Sørensen SJ, Steves CJ, Thorsen J, Timpson NJ, Tito RY, Vieira-Silva S, Völker U, Völzke H, Võsa U, Wade KH, Walter S, Watanabe K, Weiss S, Weiss FU, Weissbrod O, Westra HJ, Willemsen G, Payami H, Jonkers DMAE, Arias Vasquez A, de Geus EJC, Meyer KA, Stokholm J, Segal E, Org E, Wijmenga C, Kim HL, Kaplan RC, Spector TD, Uitterlinden AG, Rivadeneira F, Franke A, Lerch MM, Franke L, Sanna S, D'Amato M, Pedersen O, et al.
Nature Genetics (2021)

Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals

Folkersen L, Gustafsson S, Wang Q, Hansen DH, Hedman ÅK, Schork A, Page K, Zhernakova DV, Wu Y, Peters J, Eriksson N, Bergen SE, Boutin TS, Bretherick AD, Enroth S, Kalnapenkis A, Gådin JR, Suur BE, Chen Y, Matic L, Gale JD, Lee J, Zhang W, Quazi A, Ala-Korpela M, Choi SH, Claringbould A, Danesh J, Davey Smith G, de Masi F, Elmståhl S, Engström G, Fauman E, Fernandez C, Franke L, Franks PW, Giedraitis V, Haley C, Hamsten A, Ingason A, Johansson Å, Joshi PK, Lind L, Lindgren CM, Lubitz S, Palmer T, Macdonald-Dunlop E, Magnusson M, Melander O, Michaelsson K, Morris AP, Mägi R, Nagle MW, Nilsson PM, Nilsson J, Orho-Melander M, Polasek O, Prins B, Pålsson E, Qi T, Sjögren M, Sundström J, Surendran P, Võsa U, Werge T, Wernersson R, Westra HJ, Yang J, Zhernakova A, Ärnlöv J, Fu J, Smith JG, Esko T, Hayward C, Gyllensten U, Landen M, Siegbahn A, Wilson JF, Wallentin L, Butterworth AS, Holmes MV, Ingelsson E, Mälarstig A.
Nature Metabolism (2020)

Genetic and Microbial Associations to Plasma and Fecal Bile Acids in Obesity Relate to Plasma Lipids and Liver Fat Content

Chen L, van den Munckhof ICL, Schraa K, Ter Horst R, Koehorst M, van Faassen M, van der Ley C, Doestzada M, Zhernakova DV, Kurilshikov A, Bloks VW, Groen AK; Human Functional Genomics Project; Riksen NP, Rutten JHW, Joosten LAB, Wijmenga C, Zhernakova A, Netea MG, Fu J, Kuipers F.
Cell Reports (2020)

Identification, Heritability, and Relation With Gene Expression of Novel DNA Methylation Loci for Blood Pressure

Huang Y, Ollikainen M, Muniandy M, Zhang T, van Dongen J, Hao G, van der Most PJ, Pan Y, Pervjakova N, Sun YV, Hui Q, Lahti J, Fraszczyk E, Lu X, Sun D, Richard MA, Willemsen G, Heikkila K, Mateo Leach I, Mononen N, Kähönen M, Hurme MA, Raitakari OT, Drake AJ, Perola M, Nuotio ML, Huang Y, Khulan B, Räikkönen K, Wolffenbuttel BHR, Zhernakova A, Fu J, Zhu H, Dong Y, van Vliet-Ostaptchouk JV, Franke L, Eriksson JG, Fornage M, Milani L, Lehtimäki T, Vaccarino V, Boomsma DI, van der Harst P, de Geus EJC, Salomaa V, Li S, Chen W, Su S, Wilson J, Snieder H, Kaprio J, Wang X.
Hypertension (2020)

Interaction between drugs and the gut microbiome

Weersma RK, Zhernakova A, Fu J.
Gut (2020)

The Effects of Urbanization on the Infant Gut Microbiota and Health Outcomes

Brushett S, Sinha T, Reijneveld SA, de Kroon MLA, Zhernakova A.
Frontiers in Pediatrics (2020)