Exposome-NL Lecture - Matej Oresic

14 Mar 2022 | 10.00 - 11.00Online

Every second Monday of the month the Young Investigators Network invites a researcher from inside or outside the Exposome-NL consortium to inspire and inform the Exposome community, and to learn from each other. The sessions will be concluded with an interactive discussion. Join us on March 14th, when Matej Oresic is our guest.


Metabolomics and exposomics in the studies of type 1 diabetes – elucidating the role of gene-environment interactions in disease pathogenesis

The incidence of several (auto)immune diseases has been increasing in many industrialised countries since the 1950s. The largest increase in type 1 diabetes (T1D) incidence was observed in children under five years of age. T1D is caused by destruction of insulin-secreting pancreatic beta cells. The strongest genetic risk factors for T1D occur within the human leukocyte antigen (HLA) gene complex, yet only 3-10% of individuals with these risk genes develop T1D. The crucial role of environmental factors, including gene-environment interactions, is thus obvious.

For unknown reasons, T1D incidence has stabilised in the last decade, particularly in the Nordic countries. Environmental triggers and specific co-morbidities that are often implicated in T1D, e.g., enterovirus infection, diet, and obesity, cannot explain this trend. However, the time trend of human exposure levels to two widely-used industrial chemicals, perfluorooctane sulfonate and perfluorooctanoic acid (PFOS and PFOA), does follow T1D incidence.

In a mother-child cohort, we recently found that high prenatal exposure to per- and polyfluoroalkyl substances (PFAS) associated with postnatal progression to islet autoantibody positivity and decreased levels of the same lipids previously found to be associated with progression to T1D. These and other recent and ongoing investigations suggest that early-life exposure to various environmental chemicals contributes to the pathogenesis of T1D as well as potentially to other diseases via the impact said exposures have on the interplay between genetic background, the gut microbiome, and lipid metabolism, which, in turn, impact host metabolism and immune system status.

Practical matters

  • We start at exactly 10:00 hrs, so make sure you are on time!
  • If you encounter problems, try to copy the url and paste it into your browser. We advise you to use Firefox or Chrome as a browser.
  • Make sure your microphone is on mute, only opening it when it is your turn to speak. This way we avoid background noises during the lecture.
  • Feel free to ask questions using the chat functionality. After the lecture we will select and answer questions.

Should you have any further questions or will encounter any problems, please feel free to reach out to the Exposome Support Office.

Online link


Matej Orešič
Professor, Ph.D.
School of Medical Sciences, Örebro University, Örebro, Sweden
Turku Bioscience Centre, University of Turku, Turku, Finland

Decoding the exposome

Decoding the exposome

Exposome-NL is a Dutch consortium of over fifty scientists from different disciplines, universities and medical centres. Together the scientists will systematically sequence the environmental factors influencing our health.

Read More