10:40 - 11:30 hrs, Polar
Dr. Menichetti is a Senior Research Scientist at the Network Science Institute (Northeastern University), and an Associate Researcher at Brigham and Women’s Hospital (Harvard Medical School). She is a statistical/computational physicist by training, and during her Ph.D. she specialized in Network Science. She currently leads the Foodome project, which aims to track the full chemical complexity of the food we consume and develop quantitative tools to unveil, at the mechanistic level, the impact of these chemicals on our health.
Naturally occurring compounds and additives lack extensive records describing their presence in food, their quantified amounts, and their binding interactions with known protein targets. As a result, the chemical complexity of our food is still largely unmapped. This sparse characterization limits our chances to develop a mechanistic understanding of how food chemicals impact our health. In recent years, the Foodome project has tackled several aspects of this challenging universe, leveraging the expertise of a diverse group of scientific communities, from computer science to epidemiology.
In this talk, I will cover some of the major scientific contributions of the Foodome project. Specifically, I will start with our efforts to create the most extensive curated library of food chemicals before exploring how this new body of knowledge prompted us to develop quantitative tools predicting protein-ligand binding and quantifying the natural scale of nutrient concentrations in food. Additionally, the nutrient patterns we observed in the food composition data have allowed us to define a metric of food processing, which we used to characterize the quality of the food supply, and to suggest public health intervention strategies with minimal impact on individuals’ dietary patterns.
The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...
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