Thomas Hankemeier

Thomas Hankemeier is full professor of Analytical BioSciences at the LACDR, Leiden University. He leads as principal investigator the Analytical BioSciences and Metabolomics group, and he is the chair of the new Division of Systems Biomedicine and Pharmacology.

His research is aiming at innovative analytical tools for metabolomics-driven systems biology in personalised health strategies.

Publications

Normalization Strategies for Lipidome Data in Cell Line Panels

Leegwater, H., Zhang, Z., Zhang, X., Hankemeier, T., Harms, A., Zweemer, A. ., Le Dévédec, S. and Kindt, A.
Journal of Chemometrics, 39: e3636 (2025)

Strategies for Using Postcolumn Infusion of Standards to Correct for Matrix Effect in LC-MS-Based Quantitative Metabolomics

Anne-Charlotte Dubbelman, Bo van Wieringen, Lesley Roman Arias, Michael van Vliet, Roel Vermeulen, Amy C. Harms, and Thomas Hankemeier
Journal of the American Society for Mass Spectrometry 2024 35 (12), 3286-3295

A comprehensive UHPLC-MS/MS method for metabolomics profiling of signaling lipids: Markers of oxidative stress, immunity and inflammation

Wei Yang, Johannes C. Schoeman, Xinyu Di, Lieke Lamont, Amy C. Harms, Thomas Hankemeier
Analytica Chimica Acta, Volume 1297, 2024, 342348, ISSN 0003-2670

Reconstruction of Glutathione Metabolism in the Neuronal Model of Rotenone-Induced Neurodegeneration Using Mass Isotopologue Analysis ....

Luojiao Huang, Nicolas Drouin, Jason Causon, Agnieszka Wegrzyn, Jose Castro-Perez, Ronan Fleming, Amy Harms, Thomas Hankemeier
Analytical Chemistry (volume 95, issue 6) (2023)

Severe COVID-19 Is Characterised by Perturbations in Plasma Amines Correlated with Immune Response Markers, and Linked to Inflammation and Oxidative Stress

Naama Karu, Alida Kindt, Adriaan J van Gammeren, Anton A M Ermens, Amy C Harms, Lutzen Portengen, Roel C H Vermeulen, Willem A Dik, Anton W Langerak, Vincent H J van der Velden, Thomas Hankemeier
Metabolites (volume 12, issue 7) (2022)

Plasma Oxylipins and Their Precursors Are Strongly Associated with COVID-19 Severity and with Immune Response Markers

Naama Karu, Alida Kindt, Lieke Lamont, Adriaan J van Gammeren, Anton A M Ermens, Amy C Harms, Lutzen Portengen, Roel C H Vermeulen, Willem A Dik, Anton W Langerak, Vincent H J van der Velden, Thomas Hankemeier
Metabolites (volume 12, issue 7) (2022)

FAIR Digital Twins for Data-Intensive Research

Erik Schultes, Marco Roos, Luiz Olavo Bonino da Silva Santos, Giancarlo Guizzardi, Jildau Bouwman, Thomas Hankemeier, Arie Baak and Barend Mons
Frontiers Big Data, 2022, issue 5

Thomas Hankemeier

Contact information

hankemeijer@lacdr.leidenuniv.nl

Leiden University
Gorlaeus Building
Einsteinweg 55
2333 CC Leiden 
Room number GW4.07

Areas of Expertise

Drug research Metabolomics Organ-on-a-chip

Decoding the exposome

Decoding the exposome

The environment we live in has a dominant impact on our health. It explains an estimated seventy percent of the chronic disease burden. Where we live, what we eat, how much we exercise, the air we breathe and whom we associate with; all of these environmental factors play a role. The combination of these factors over the life course is called the exposome. There is general (scientific) consensus that understanding more about the exposome will help explain the current burden of disease and that it provides entry points for prevention and ...

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